As a young girl, Shriek had a miserable childhood that eventually drove her to drugs. Her mother was ashamed of her for being overweight and she was abused by both her parents. She became a groupie for a rock band, and a drug dealer on the side until the vigilantes Cloak and Dagger happened by during one of her deals. Having already suffered enough traumas to make her dangerously unstable, a short stay in Cloak's dark dimension pushed her over the edge into insanity. After that, she was captured and imprisoned in Ravencroft. According to her, she was also shot in the head by police and while gluing the pieces together again, the doctors apparently missed some. However, it is still unclear as to how her powers actually developed. It could be that she already had these powers but they didn’t manifest themselves until she was exposed to Cloak’s darkness, or they could have been a side effect of the drugs she was taking, or it could have been a combination of these events, among others, that caused her powers to develop.

When the menace Carnage was imprisoned and escaped from Ravencroft, Shriek talked him into taking her with him. After that, they met with Doppelganger, Demogoblin and Carrion (Malcolm McBride). Shriek's childhood problems of being obsessed with families started to surface, and she adopted Carnage as her husband, Carrion and Demogoblin as their children to which she would teach their evil ways, and Doppelganger became their adopted pet. Carnage, demented in his own right, went along with this dysfunctional family idea of hers. During this episode in Spider-Man’s life now referred to as Maximum Carnage, Shriek used her powers to induce everyone they came across in the city of New York to be evil. Shriek and her adopted family had to battle Spider-Man and several of his allies such as Black Cat, Iron Fist, and Venom. Doppelganger had become close to Shriek and gave his life to protect her when Carnage attacked her for her rebellious behavior. The fighting within the Carnage Family became too much and with the death of Doppelganger, Carrion seemingly rid of the virus inside him, and Demogoblin wanting to repent for his murderous ways, Shriek thought she too had seen the light. Shriek was returned to Ravencroft after the events of Maximum Carnage.

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